XtaLAB Synergy-i

Overview

The XtaLAB Synergy-i is a full-sized single crystal X-ray diffractometer built for structural analysis of small molecule samples and includes a high-precision 4-circle kappa-geometry goniometer; the system now comes equipped with the UG3 goniometer for faster, more efficient data collections. The instrument is configured with a HyPix-Bantam hybrid solid-state pixel array detector that enables direct X-ray photon detection and counting, producing essentially noise-free images by assessing photon energy at the moment of detection. The standard X-ray source is the PhotonJet-i microfocus sealed tube with a graded multi-layer mirror, available with Mo or Cu targets and configurable as single- or dual-source; closed-circuit water cooling is used to control tube temperature and maintain reproducible flux. The XtaLAB Synergy-i is controlled by CrysAlisPro software offering automated crystal screening, strategy calculation, concurrent data reduction and automatic small molecule structure solution, and can be paired with optional AutoChem for fast, fully automatic structure solution and refinement during data collection. Physical and system specifications listed for the core unit include Dimensions: 1300 (W) x 1875 (H) x 850 (D) (mm); Mass: 550 kg (core unit); Power requirements: 1Ø, 90-130 V, 10 A or 180-260 V, 4 A; accessories include Internal monitor in cabinet, Oxford Cryostream 1000, Oxford Cobra, XtalCheck-S and High Pressure Kit; computer requirements: External PC, MS Window® OS with CrysAlisPro software. The XtaLAB Synergy-i is described as an ideal diffractometer for chemical crystallography research laboratories and is intended for structural analysis of small molecule samples. Its HyPix-Bantam direct photon-counting detector and essentially noise-free imaging support investigation of weakly diffracting crystals by enabling longer counting without loss of data quality, and the integrated "What is this?" feature (with optional AutoChem) can determine sample identity in seconds before committing to a full dataset. Application notes relevant to this product cover topics including: PHRM0001 - Crystalline Sponge Method on XtaLAB Synergy Systems; B-SCX1011 - High-Speed Measurement Of A Peptide Drug Using HyPix-Arc 150°; SMX029 - What Is This? and Data Collection on Metal-organic Framework Microcrystals using the XtaLAB Synergy-S; SMX010 - A Study of the Stereochemistry of Sucrose and a Phenidate Derivative using the Copper Microfocus Source of the XtaLAB Synergy-i; SMX004 - Using CrysAlisPro to Elucidate Twinned Crystals by X-ray Diffraction; SMX019 - The HyPix-6000HE Detector and Its Ability to Resolve Reflections at Close Crystal-to-Detector Distances; SMX039 - The Absolute Structure of Light-atom-containing Molecules; SMX034 - The Molecular Grabber Method: Another Crystalline Sponge using Protein; SMX018 - Structures in Seconds with What Is This?; SMX011 - Superior Data Quality Achieved with the XtaLAB Synergy-i, Microfocus Mo source; SMX038 - Rigaku Rotating Anodes: Powerful and Reliable Sources for Seamless and High-throughput Small Molecule Structure Solution; SMX032 - PDF Analysis of Glassy Materials on a Home Laboratory Diffractometer; SMX027 - Micro Powder Diffraction on XtaLAB Synergy Single Crystal Diffractometers; SMX017 - Determining Structure of Volatile Compounds with the Crystalline Sponge Method; SMX036 - Comparison of Two XtaLAB Synergy Instruments; SMX024 - Charge-density Data Collection on XtaLAB Synergy Diffractometers; and SMX030 - Application of the Crystalline Sponge Method for Structure Determination of Persistent organic Pollutants of Agrochemical Degradation Products.